Although some women have preserved ovarian reserve for the long period of time (although the chances of pregnancy after the age of 40 are not particularly good), in a certain number of women, ovarian reserve is exhausted earlier than in natural flow due to some genetic predispositions, certain systemic diseases, as well as a variety of other diseases, primarily endometriosis, and previous operations on ovaries.
This condition is called Premature ovarian insufficiency (POI) or Premature ovarian failure (POF), when the exhaustion of ovarian function performs prior the age of 40, sometimes even 10 years before the specified period, which causes very small chances of pregnancy that occurs spontaneously, as well as through the IVF procedure.
In most cases situation is predictable; it is a result of before mentioned previous interventions. What we consider as a real POF (a result of certain genetic disorder- FMR1 multiplication) occurs in only 1% of women. Although this is not a negligible percentage, our experiences suggest that a far greater number of women in the process of IVF have a reduced ovarian reserve. The reasons may be numerous, and certainly harmful lifestyle and environmental factors play a significant role in this problem.
There are certain treatment options, especially hormone based like DHEA treatment of certain coenzyme and a number of other treatment options that are the more or less successfully applied in order to increase ovarian response in these situations.
Unfortunately, older reproductive age today represents the biggest challenge and the biggest problem which couple with infertility problem is facing with, in which a medicine is not and probably never will be able to find a solution.Learn more
Anti-Mullerian hormone - AMH represents one of the basic, the most commonly used tests, or indicators of ovarian reserve. In biological terms, AMH is a glycoprotein of transforming growth factor (TGF) beta superfamily, and in the women is produced exclusively in granulosa cells, prenatal and small antral follicles. Anti-Mullerian hormone gene is located on chromosome 19.Learn more
Although some women have preserved ovarian reserve for the long period of time (although the chances of pregnancy after the age of 40 are not particularly good), in a certain number of women, ovarian reserve is exhausted earlier than in natural flow due to some genetic predispositions, certain systemic diseases, as well as a variety of other diseases, primarily endometriosis, and previous operations on ovaries.Learn more
The tests for ovarian reserve preservation status are all diagnostic procedures with which we assess and quantify the state of ovarian reserve or ovarian functional capacity. These are all procedures that a doctor conducts in order to gain insight into the ovary conditions, and to determine the best therapeutic plan for further treatment.Learn more
Antral follicles are small follicles in the ovaries, with diameter of 2 mm, which can be detected by transvaginal ultrasound and the number of which is a very reliable test of ovarian reserve preservation. AFC means the number of those follicles on both ovaries.Learn more
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