About IVF

Ovarian reserve

Ovarian reserve, by definition, involves the size and quality of the remaining ovarian follicular group. Translated into ordinary language, ovarian reserve means a reserve in the number of ovarian oocytes, or real - biological age of the ovaries. As noted women are born with a certain number of eggs that cannot be regenerated, and this number with age (especially after age of 37) starts to fall drastically. Decrease in numbers, is often accompanied by a decline in the quality of eggs. Examination of ovarian reserve is of crucial importance in the treatment of infertility and gynecology in general since the physician and the patient gives an insight into the situation and allows them to make the best plan for future. The subspecialists for sterility see tests for ovarian reserve (the diagnostic procedures used to evaluate ovarian reserve) as an identification document of patient. Therapeutic approach often depends on these tests and in the cases of reduced ovarian reserve, the doctor and a couple will far more quickly decide for those therapeutic option that gives the best chance for pregnancy, such as In vitro fertilization. Assessment of ovarian reserve serves to create the basics of reproductive plans for couple, forecasting menopause, as well as the basis for selection of the type of infertility treatments and designing protocols stimulation in In vitro fertilization procedure.

Age and reproductive function

Unfortunately, older reproductive age today represents the biggest challenge and the biggest problem which couple with infertility problem is facing with, in which a medicine is not and probably never will be able to find a solution.

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Anti-Mullerian hormone – AMH

Anti-Mullerian hormone - AMH represents one of the basic, the most commonly used tests, or indicators of ovarian reserve. In biological terms, AMH is a glycoprotein of transforming growth factor (TGF) beta superfamily, and in the women is produced exclusively in granulosa cells, prenatal and small antral follicles. Anti-Mullerian hormone gene is located on chromosome 19.

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Diminished ovarian reserve

Although some women have preserved ovarian reserve for the long period of time (although the chances of pregnancy after the age of 40 are not particularly good), in a certain number of women, ovarian reserve is exhausted earlier than in natural flow due to some genetic predispositions, certain systemic diseases, as well as a variety of other diseases, primarily endometriosis, and previous operations on ovaries.

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The tests for ovarian reserve preservation status

The tests for ovarian reserve preservation status are all diagnostic procedures with which we assess and quantify the state of ovarian reserve or ovarian functional capacity. These are all procedures that a doctor conducts in order to gain insight into the ovary conditions, and to determine the best therapeutic plan for further treatment.

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Number of antral follicles – AFC determination

Antral follicles are small follicles in the ovaries, with diameter of 2 mm, which can be detected by transvaginal ultrasound and the number of which is a very reliable test of ovarian reserve preservation. AFC means the number of those follicles on both ovaries.

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