About IVF

Tests of ovarian reserve

Test of ovarian reserve represents all diagnostic procedures through which the state of ovarian reserve or of ovaries functional capacity is estimated. These are all procedures that are conducted in order to gain an insight into the ovary conditions, and to determine the best therapeutic plan for further treatment. Test of ovarian reserve is the basis for treatment for couples with infertility problem, and without it, the proper diagnose and curing of the couple is not possible. Tests are also the basis for stimulation protocols in the process of In vitro fertilization. Tests of ovarian reserve through ultrasound exams, represent counting of antral follicles (antral follicle count - AFC), measuring the size of the ovaries with 3D sonography, as well as Studies of the flow through blood vessels of the pelvis. Key hormonal tests represent determination of the level of reproductive hormones on the 3rd day of the cycle: level of FSH, LH, E2, and AMH.

Age and reproductive function

Unfortunately, older reproductive age today represents the biggest challenge and the biggest problem which couple with infertility problem is facing with, in which a medicine is not and probably never will be able to find a solution.

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Anti-Mullerian hormone – AMH

Anti-Mullerian hormone - AMH represents one of the basic, the most commonly used tests, or indicators of ovarian reserve. In biological terms, AMH is a glycoprotein of transforming growth factor (TGF) beta superfamily, and in the women is produced exclusively in granulosa cells, prenatal and small antral follicles. Anti-Mullerian hormone gene is located on chromosome 19.

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Diminished ovarian reserve

Although some women have preserved ovarian reserve for the long period of time (although the chances of pregnancy after the age of 40 are not particularly good), in a certain number of women, ovarian reserve is exhausted earlier than in natural flow due to some genetic predispositions, certain systemic diseases, as well as a variety of other diseases, primarily endometriosis, and previous operations on ovaries.

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The tests for ovarian reserve preservation status

The tests for ovarian reserve preservation status are all diagnostic procedures with which we assess and quantify the state of ovarian reserve or ovarian functional capacity. These are all procedures that a doctor conducts in order to gain insight into the ovary conditions, and to determine the best therapeutic plan for further treatment.

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Number of antral follicles – AFC determination

Antral follicles are small follicles in the ovaries, with diameter of 2 mm, which can be detected by transvaginal ultrasound and the number of which is a very reliable test of ovarian reserve preservation. AFC means the number of those follicles on both ovaries.

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