Although the most effective method for the achievement of pregnancy, in vitro fertilization is not omnipotent and is not a "magic wand" in struggle with infertility.
The failed attempts of In vitro fertilization is a source of huge frustration for both patients and for the entire IVF team. Although the chance of success of IVF cycles is good and reaches over 50% in certain situations, this procedure is still not a "magic wand" and a certain percentage of patients will fail the first or even several attempts.
Specific clinical cases are recurrent unsuccessful attempts. Its definition is not uniform, and depends not only on the number of attempts, but also on the number and quality of returned embryos. In our environment it is considered that this is a situation where there is no pregnancy even after 2 cycles of IVF in which we have high-quality embryos with the return of more than one embryo.
The most common reason for failure lies in the inadequate genetic constitution of an embryo that could have morphologically normal findings. It is believed that in over 80% of cases of failure, chromosomally defective embryo is the main reason for the failure. The fact is that for woman after the age of 35, a chance for failure starts to grow, so that after the age of 40, even up to 90% of embryos are genetically defective.
In order to prevent failure, we can suggest to the patient Preimplantation Genetic screening of embryos to the number of chromosomes (PGS), by which we can ensure proper transfer just of those embryos which are genetically correct embryos, and spare couple of trauma that failure carries.
The main cause for the remaining 20% of cases of failure, is insusceptibility of the uterus for the reception of the embryo. There are certain disorders among women which can further contribute to failure, that are not examined in the context of standard diagnosis of infertility.
These disorders require additional diagnostics before the next IVF attempt, in order to be eventually diagnosed, subsequently treated, and thereby a greater chance for success in subsequent cycles is expected.
Disorders to examine in these situations are:
• Hematologic and immune causes, with special preference to the creation of thrombus (thrombophilia), and the possible compromising of the process of embryos implantation and its nutrition
• The presence of antiphospholipid antibodies (anticardiolipin antibodies), lupus anticoagulant antibodies, as well as numerous disturbances from groups such as thrombophilia abnormanog Factor V Leiden, MTHFR mutations Lack of protein C and protein S, PAI I, F II G20210A
• Genetic testing of both partners
• PGD and PGS
• Endocrine disorders (complete function of the thyroid gland, prolactin and Reproductive shaft)
• Anatomical factors (number of pathological conditions in the womb that are diagnosed and treated hysteroscopic)
• Infectious causes (a number of viral and bacterial infections, such as Mycoplasma, Ureaplasma, Chlamydia, CMV, and other) may account the failure of IVF
Psychological stress can negatively affect the entire course of treatment, not so much in terms of reduced chances of success, as much in terms of degradation of the quality of life of women, men and the couple in general, and this is a very important factor.Learn more
Multiple pregnancies represent the presence of more than one fetus in the cavum of the uterus, most often it comes to twin pregnancy, but also to triple pregnancy - triplets, while the higher-order multiple births are rare.Learn more
In certain situations when the number or quality of remaining egg cells is lower, the best and sometimes the only form of successful treatment of infertility represents a cycle with donated egg cells.Learn more
As the In vitro fertilization is not a "magic wand" that guarantees success, so it would not be correct to say that certain foods, and related type of diet certainly leads to an increased chance of success, as well as believing in miraculous plants that lead to a cure for infertility, although some herbal preparations can have a positive effect to the number of processes in these proceedings.Learn more
Acupuncture represents an ancient Chinese medical procedure used for centuries to treat a number of diseases. According to traditional Chinese medicine, the human body contains life energy - chi, which travels through the body along the defined meridians, and controls all the vital functions.Learn more
Ovarian hyper stimulation syndrome - OHSS represents one of the biggest complications of treatments of infertility and in vitro fertilization.
This condition may end fatally, and it is estimated that this tragic outcome occurs in 3/100 000 initiated cycles of in vitro fertilization, as a result of OHSS.