Reduced ovarian reserve

Although some women have preserved ovarian reserve for the long period of time (although the chances of pregnancy after the age of 40 are not particularly good), in a certain number of women, ovarian reserve is exhausted earlier than in natural flow due to some genetic predispositions, certain systemic diseases, as well as a variety of other diseases, primarily endometriosis, and previous operations on ovaries. This condition is called Premature ovarian insufficiency (POI) or Premature ovarian failure (POF), when the exhaustion of ovarian function performs prior the age of 40, sometimes even 10 years before the specified period, which causes very small chances of pregnancy that occurs spontaneously, as well as through the IVF procedure. In most cases situation is predictable; it is a result of before mentioned previous interventions. What we consider as a real POF (a result of certain genetic disorder- FMR1 multiplication) occurs in only 1% of women. Although this is not a negligible percentage, our experiences suggest that a far greater number of women in the process of IVF have a reduced ovarian reserve. The reasons may be numerous, and certainly harmful lifestyle and environmental factors play a significant role in this problem. There are certain treatment options, especially hormone based like DHEA treatment of certain coenzyme and a number of other treatment options that are the more or less successfully applied in order to increase ovarian response in these situations.